Nope card

There are 5 Nope cards in the deck. A Nope card stops any action except for an Exploding Kitten or a Defuse card. Imagine that any card (or Pair or Special Combo) beneath a Nope card no longer exists. You can also play a Nope on another Nope to create a double negative Yup, and so on. You can play a Nope card at any time before an action has begun, even if it's not your turn.